New Antidepressants

SSRIs act by inhibiting serotonin reuptake, and are considered the most popular, effective and safe drugs. The new prescription SSRIs used to treat depression include citalopram (Celexa), escitalopram oxalate (Lexapro), fluoxetine (Prozac, Prozac Weekly, Sarafem), paroxetine (Paxil, Paxil CR) and sertraline (Zoloft) . Citalopram, a chiral compound, has activity of inhibiting the reuptake of serotonin in the S-enantiomer. Escitalopram, the S-enantiomer of the antidepressant citalopram has demonstrated activity in animal models. Prozac has shown great success in the treatment of depression and suicide prevention. It has fewer side effects compared with TCAs and MAOIs. Paroxetine exhibits anti-cholinergic effect and causes sedation. Zoloft a few drug interactions but has the side effect of causing diarrhea and male sexual dysfunction.

IRSN is currently available (desipramine, Duloxetine, nefazodone, and venlafaxine) keep both serotonin and norepinephrine at relieving symptoms of depression. Nefazodone alleviates anxiety, sedation and causes positive effects on sleep. Venlafaxine (Effexor) has anticholinergic effects (dry mouth, blurred vision, urinary hesitancy and constipation), induces sedation and the potential effects of withdrawal.

The drug bupropion (Wellbutrin, Wellbutrin SR) is the most commonly used member of the novel Antidepressant class. It is quite unique in its effectiveness in inhibiting the reuptake of dopamine, serotonin and norepinephrine. Reuptake receipt of declining well-being of the brain chemicals. Maprotiline (Ludiomil) and mirtazapine (Remeron) are the two main drug group tetracyclic antidepressants. Mirtazapine works by increasing the amount of norepinephrine and serotonin, and is particularly beneficial for the treatment of depression accompanied by anxiety, agitation and / or sleep disorders.